Table 3.
pdVWF/FVIII Population PK and PD Models: Patient Baseline Characteristics
| VWF:RCo PK Model Population | FVIII PK/PD Model Population | |
|---|---|---|
| No. of patients | 20 | 20 |
| No. of samples | 281 | 281 |
| No. of samples >LLOQ | 232 | 281 |
| No. of samples <LLOQ | 49 | 0 |
| Continuous covariates, median (range) | VWF:RCo PK and FVIII PD | |
| Age, years | 30 (18–60) | |
| Body weight, kg | 66.3 (43.8–132) | |
| Hematocrit, L/L | 0.406 (0.334–0.483) | |
| Categorical variables, n (%) | ||
| Sex | ||
| Male | 9 (45) | |
| Female | 11 (55) | |
| Race | ||
| White | 20 (100) | |
| Disease type | ||
| Type 3 VWD | 20 (100) | |
Abbreviations: FVIII, factor VIII; LLOQ, lower limit of quantification; PD, pharmacodynamic; pdVWF/FVIII, plasma-derived von Willebrand factor/FVIII; PK, pharmacokinetic; VWD, von Willebrand disease; VWF:RCo, von Willebrand factor:ristocetin cofactor.