Figure 1.

Flow chart to represent various novel strategies to treat Aqueous-Deficient Dry eye Disease (ADDE), Evaporative Dry eye (EDE) and Mixed variant of the disease using nanotechnology, biomedical engineering and regenerative medicine. Approach to newer drug delivery strategies in all variants of the dry eye includes using newer nano drug delivery systems, hydrogels and drug-eluting contact lenses to improve the drug bioavailability at the ocular surface. The approach to improve the ocular surface by immunomodulation, paracrine activity and repair properties of MSC (mesenchymal stem cells) or their secretome is a vast area of research in EDE and the Mixed variant of the disease. Finally approach to regenerate lacrimal glands by bioengineering strategies remains a possible strategy to tackle ADDE