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. 2023 Jun 17;14:3613. doi: 10.1038/s41467-023-39307-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cryo-EM map of human Na_v1.7 bound to CBD. The Na_v1.7 complex comprises the transmembrane α1 subunit (domain colored), the auxiliary β1 subunit (light salmon), and β2 subunit (salmon). Sugar moieties and lipids are colored gray and orange, respectively. The same color scheme is applied throughout the manuscript. b Overall structure of the α1 subunit of Na_v1.7 bound to CBD. Two CBD molecules, designated as CBD-1 and CBD-2 and shown as light grey spheres, bind to different sites in the pore domain (PD). c Two CBD-binding sites, the inactivation receptor site (the I-site, right) for CBD-1 and the I-IV fenestration site (the F-site, left) for CBD-2, are identified and highlighted with magenta and gray boxes, respectively.