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. 2023 Jun 17;13:9841. doi: 10.1038/s41598-023-37007-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ERβ partially mediates 17α-E2 effects on mass and adiposity in obese female, but not male, mice. (A) Percent change in body mass over time [n = 9–10/group/timepoint], (B) Body mass at baseline (week 0; striped) and week 10 (solid) [n = 9–10/group/timepoint], (C) Percent change in fat mass over time [n = 9–10/group/timepoint], and (D) Fat mass at baseline (week 0; striped) and week 10 (solid) [n = 9–10/group/timepoint] in male WT and ERβKO mice. (E) Percent change in body mass over time [n = 7–9/group/timepoint], (F) Body mass at baseline (week 0; striped) and week 10 (solid) [n = 7–9/group/timepoint], (G) Percent change in fat mass over time [n = 7–9/group/timepoint], and (H) Fat mass at baseline (week 0; striped) and week 10 (solid) [n = 7–9/group/timepoint] in female WT and ERβKO mice. Age-matched, WT, LFD-fed mice were also evaluated as a normal-weight reference group and their corresponding means for both sexes are depicted as dashed yellow lines [n = 9/group/timepoint]. All data are presented as mean ± SEM and were analyzed within sex by two-way repeated measures ANOVA with Tukey post-hoc comparisons. For panels (A), (C), (E) and (G), * represents differences between WT HFD and WT HFD + 17α-E2, while # represents differences between ERβKO HFD and ERβKO HFD + 17α-E2. For panels (B), (D), (F), and (H), * represents differences within treatment group over time. *^,#p < 0.05.