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. 2023 Jun 17;13:9841. doi: 10.1038/s41598-023-37007-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ERβ partially regulates 17α-E2-mediated effects on markers associated with hepatic steatosis and fibrosis in a sex-specific manner. (A) SCD1 protein [n = 7/group], (B) Representative immunoblots of SCD1 and GAPDH, and (C) TGF-ꞵ1 protein [n = 7/group] in liver from male WT and ERβKO mice. (D) SCD1 protein [n = 5/group], (E) Representative immunoblots of SCD1 and GAPDH, and (F) TGF-ꞵ1 protein [n = 7/group] in liver from female WT and ERβKO mice. Age-matched, WT, LFD-fed mice were also evaluated as a normal-weight reference group and their corresponding means for both sexes are depicted as dashed yellow lines [n = 5–7/group]. All data are presented as mean ± SEM and were analyzed within sex by two-way ANOVA with Tukey post-hoc comparisons. * represents differences within genotypes across treatment groups. *p < 0.05.