Table 1.
The Clinical Characteristic in MPNP, BNP, and NNP
| MPNP(n=42) | BNP(n=78) | NNP (n=142) | P | |
|---|---|---|---|---|
| Baseline information | ||||
| Age (mean (SD)), y | 5.72 (3.89) | 5.43 (3.89) | 4.65 (4.01) | 0.187 |
| Weight (mean (SD)), kg | 19.40 (10.91) | 19.30 (12.16) | 15.17 (8.42) | 0.004 |
| Sex (boy), n (%) | 21 (50.0) | 39 (50.0) | 51 (35.9) | 0.071 |
| Clinical feature | ||||
| Cough, n (%) | 40 (95.2) | 62 (79.5) | 133 (93.7) | 0.002 |
| Hemoptysis, n (%) | 1 (2.4) | 1 (1.3) | 4 (2.8) | 0.766 |
| Chest pain, n (%) | 5 (11.9) | 13 (16.7) | 14 (9.9) | 0.336 |
| Wheeze, n (%) | 3 (7.1) | 16 (20.5) | 19 (13.4) | 0.119 |
| Shortness of breath, n (%) | 4 (9.5) | 21 (26.9) | 22 (15.5) | 0.032 |
| Rales, n (%) | 13 (16.7) | 16 (38.1) | 42 (29.6) | 0.026 |
| Duration of fever (median [IQR]), d | 9.00 [5.25, 15.00] | 7.50 [4.00, 13.50] | 10.00 [7.00, 15.00] | 0.012 |
| Peak body temperature (median [IQR]), °C | 39.50 [39.20, 39.90] | 39.50 [39.23, 40.00] | 39.50 [39.00, 39.80] | 0.074 |
| Haematogenous spread | 0 (0.0) | 8 (10.3) | 3 (2.1) | 0.005 |
| Radiological features | ||||
| Lobar consolidation, n (%) | 15 (35.7) | 22 (28.2) | 42 (29.6) | 0.677 |
| Pleural effusion, n (%) | 18 (42.9) | 32 (41.0) | 59 (41.5) | 0.981 |
| Complications | ||||
| Digestive system, n (%) | 12 (28.6) | 32 (41.0) | 33 (23.2) | 0.021 |
| Nervous system, n (%) | 1 (2.4) | 3 (3.8) | 4 (2.8) | 0.88 |
| Urinary tract system, n (%) | 0 (0.0) | 1 (1.3) | 1 (0.7) | 0.738 |
| Circulatory system, n (%) | 4 (9.5) | 13 (16.7) | 7 (4.9) | 0.015 |
| Endocrine system, n (%) | 2 (4.8) | 3 (3.8) | 2 (1.4) | 0.37 |
| Blood system, n (%) | 5 (11.9) | 25 (32.1) | 24 (16.9) | 0.009 |
| Laboratory values | ||||
| WBC (median [IQR]), 109/L | 10.20 [7.60, 16.49] | 14.87 [10.02, 17.59] | 12.97 [10.12, 17.79] | <0.001 |
| Hb (median [IQR]), g/L | 116.00 [101.25, 126.75] | 115.00 [102.00, 124.00] | 107.50 [92.00, 118.00] | 0.003 |
| PLT (median [IQR]), 109/L | 360.00 [265.00, 499.25] | 413.50 [286.00, 579.00] | 470.50 [383.00, 601.00] | 0.002 |
| N% (median [IQR]) | 61.40 [46.62, 72.60] | 69.85 [58.62, 79.15] | 59.20 [48.73, 71.27] | <0.001 |
| L% (median [IQR]) | 24.30 [17.52, 42.75] | 20.80 [13.27, 30.25] | 28.90 [19.12, 39.33] | 0.001 |
| CRP (median [IQR]), mg/L | 45.51 [11.85, 93.50] | 77.97 [20.34, 160.64] | 51.74 [11.26, 117.94] | 0.037 |
| PCT (median [IQR]), ng/mL | 0.60 [0.31, 1.60] | 1.77 [0.28, 2.98] | 1.60 [0.60, 2.60] | <0.001 |
| AST (median [IQR]), U/L | 18.50 [12.00, 39.00] | 17.00 [12.00, 30.75] | 19.00 [12.00, 35.30] | 0.904 |
| ALT (median [IQR]), U/L | 32.00 [26.00, 45.75] | 29.00 [22.00, 50.00] | 33.00 [25.00, 52.50] | 0.361 |
| LDH (median [IQR]), U/L | 272.70 [238.75, 402.50] | 335.00 [278.00, 499.00] | 298.00 [233.00, 368.80] | 0.019 |
| Alb (median [IQR]), g/L | 35.70 [31.30, 39.65] | 31.90 [28.30, 35.10] | 33.30 [29.08, 36.12] | 0.013 |
| PT (median [IQR]), s | 13.10 [12.10, 13.60] | 13.30 [12.50, 14.00] | 12.40 [11.50, 13.00] | <0.001 |
| APTT (median [IQR]), s | 34.60 [27.52, 36.77] | 34.75 [30.40, 37.08] | 30.10 [25.63, 34.25] | <0.001 |
| FG (median [IQR]), g/L | 4.02 [2.58, 5.49] | 4.76 [3.77, 5.96] | 4.52 [3.36, 5.02] | 0.008 |
| Treatment | ||||
| Glucocorticoid, n (%) | 12 (28.6) | 27 (34.6) | 24 (16.9) | 0.01 |
| ICU admission, n (%) | 3 (7.1) | 14 (17.9) | 6 (4.2) | 0.002 |
| Thoracic close drainage, n (%) | 2 (4.8) | 9 (11.5) | 16 (11.3) | 0.435 |
| Lobectomy, n (%) | 2 (4.8) | 10 (12.8) | 22 (15.5) | 0.191 |
| Duration of hospitalization (mean (SD)), d | 13.50 [9.00, 20.75] | 21.00 [12.00, 32.50] | 18.00 [12.00, 24.00] | 0.011 |
| Hospitalization expenses (median [IQR]), $ | 2824.06 [1627.81, 4149.66] | 4088.24 [1968.72, 5708.89] | 3337.12[1826.98, 4455.10] | 0.169 |
Abbreviations: WBC, white blood cell; Hb, hemoglobin; PLT, platelet; N%, Percentage of neutrophils; L%, Percentage of lymphocytes; CRP, C -reactive protein; PCT, procalcitonin; ALT, alanine aminotransferase; AST, alanine aminotransferase; Alb, albumin; LDH, lactate dehydrogenase; PT, Prothrombin time; APTT, activated partial thromboplastin time; FG, fibrinogen; IVIG, intravenous immune globulin; ICU, intensive care unit.