Table 3.

Inclusion Complexes with Cyclodextrin and Their Applications

Year	Kind of CD	Drug	Formulation	Application	Ref.
2019	β-CD	Basil and Pimenta dioica essential oils	Antimicrobial food preservation sachets	Improves thermal stability, decreases volatility, and increases the release duration of the essential oils	[27]
2016	β‐CD	Erlotinib	Nanosponge	Enhance solubility, dissolution rate, in vitro cytotoxicity, and oral bioavailability	[28]
2007	β‐CD and HP-β‐CD	5-fluorouracil	Thermosensitive mucoadhesive vaginal gel	Increases the drug aqueous solubility and release rate	[29]
2009	HP-β‐CD	Cisplatin	Solid inclusion complex		[41]
2016	β‐CD	Curcumin	Solid dispersion	Enhanced drug delivery and improved its therapeutic efficacy	[42]
2018	β-CD, SBE-β‐CD, and HP-β-CD	Amlodipine Limonin	Ophthalmic preparation	Improved ocular permeation and effectiveness of drug	[43]
2018	β‐CD and γ‐CD	Limonin Albendazole	Orange juice	Significant reduction of bitter taste and keep the anti-inflammatory effects of Limonin	[44]
2007	HP-β‐CD	Albendazole and Ricobendazole	Solid complex	Increase the drug solubility and efficacy with no signs of toxicity	[45]
2020	α-CD, β‐CD, and γ‐CD; and their derivatives (HP-β-CD, and 2,6-di-O-methyl)-β-CD (DM-β-CD)	2R,3R-Dihydromyricetin flavonoid	1:1 stoichiometric inclusion complex	Enhanced the radical scavenging capacity of the drug and maintained its lipid-lowering effect (anti-hyperlipidemia)	[46]
2019	β-CD	Tebipenem pivoxil	Solid inclusion complex	Improved drug chemical stability and antibacterial activity	[19]
2011	PM-CD, α-CD, β-CD and γ-CD, and HP-α-CD, HP-β-CD and HP-γ-CD	Lonidamine		Improved the solubility, bioavailability, and anticancer activity	[47]