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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Pain. 2022 Dec 19;164(7):1473–1488. doi: 10.1097/j.pain.0000000000002850

Figure 1 – Domain structure of NRP1 and docking of NRP1–4 to NRP1.

Figure 1 –

(A) Domain architecture of NRP1 consists of the extracellular N-terminus (N), tandem CUB domains (a1, a2), tandem F5/8 type C domains (b1, b2), a MAM domain, the transmembrane helix (TM) and the cytoplasmic PDZ domain (C). (B) Surface representation of the b1 domain with docked NRP1–4 (gold sticks). (C) Close-up of NRP1–4 docked to the VEGF-A CENDR binding pocket. Potential hydrogen bonds indicated with dashed lines. Docking was done as described by Perez-Miller, S., et al. 2021 [55].