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. 2023 Jun 5;14:1160148. doi: 10.3389/fimmu.2023.1160148

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Copyright © 2023 Nolde, Alayash, Reckelkamm, Kocher, Ehmke, Holtfreter, Baurecht, Georgakis and Baumeister

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-6 signaling. Variants in the IL6R gene act as proxies for downregulation of IL-6 signaling. SNPs in this region that are strongly associated with CRP are assumed to act via modifying IL-6 receptors.