Table 1.
Summary of CRP associated variants in IL6R.
| SNP | EA | OA | EAF | BETA | SE | P-value | F statistic |
|---|---|---|---|---|---|---|---|
| rs10796927 | T | C | 0.729 | 0.040 | 0.002 | 2.5e-71 | 330.6 |
| rs111879666 | T | C | 0.039 | -0.055 | 0.005 | 1.5e-28 | 122.3 |
| rs112203594 | A | C | 0.013 | 0.038 | 0.007 | 2.4e-08 | 31.3 |
| rs112505856 | T | C | 0.052 | -0.041 | 0.006 | 1.2e-11 | 46.1 |
| rs11264239 | A | G | 0.057 | -0.038 | 0.005 | 1.3e-16 | 67.9 |
| rs113580743 | A | G | 0.038 | 0.051 | 0.005 | 1.4e-21 | 90.8 |
| rs116037345 | T | C | 0.043 | 0.036 | 0.006 | 2.5e-09 | 35.6 |
| rs116059394 | A | G | 0.951 | -0.046 | 0.004 | 2.5e-24 | 102.7 |
| rs116141616 | A | G | 0.018 | 0.037 | 0.006 | 9.5e-09 | 33.1 |
| rs11811450 | A | G | 0.913 | -0.022 | 0.004 | 2.7e-10 | 39.1 |
| rs12083537 | A | G | 0.807 | 0.066 | 0.002 | 3.1e-159 | 749.4 |
| rs12406117 | A | G | 0.587 | 0.013 | 0.002 | 6.5e-11 | 44.2 |
| rs12726220 | A | G | 0.927 | 0.025 | 0.004 | 1.3e-08 | 32.1 |
| rs12735458 | A | G | 0.987 | 0.077 | 0.009 | 1.1e-18 | 77.2 |
| rs12750774 | A | G | 0.308 | -0.063 | 0.002 | 2.0e-191 | 902.9 |
| rs139364224 | T | C | 0.979 | -0.060 | 0.008 | 5.9e-15 | 61.5 |
| rs139952834 | T | C | 0.029 | 0.064 | 0.009 | 3.3e-12 | 48.1 |
| rs142768042 | T | C | 0.020 | 0.040 | 0.006 | 4.7e-11 | 43.4 |
| rs144671207 | A | G | 0.018 | -0.056 | 0.009 | 1.6e-09 | 36.1 |
| rs145262901 | A | G | 0.018 | -0.057 | 0.010 | 7.0e-09 | 33.4 |
| rs145909430 | T | C | 0.987 | 0.103 | 0.008 | 2.3e-39 | 174.0 |
| rs147830103 | A | G | 0.041 | 0.043 | 0.007 | 7.1e-10 | 38.3 |
| rs16835819 | T | C | 0.989 | 0.080 | 0.009 | 1.4e-20 | 85.6 |
| rs1760798 | T | C | 0.769 | -0.018 | 0.002 | 2.9e-14 | 59.9 |
| rs183641528 | A | G | 0.013 | -0.080 | 0.008 | 7.3e-26 | 111.6 |
| rs1889312 | A | G | 0.428 | -0.022 | 0.002 | 6.5e-28 | 124.3 |
| rs3738028 | A | C | 0.560 | 0.015 | 0.002 | 1.2e-11 | 47.7 |
| rs3766925 | A | T | 0.256 | -0.015 | 0.002 | 6.4e-11 | 44.3 |
| rs3766926 | T | C | 0.805 | -0.046 | 0.002 | 1.0e-78 | 365.8 |
| rs41269913 | T | C | 0.045 | -0.040 | 0.005 | 2.3e-13 | 53.7 |
| rs4133213 | A | C | 0.393 | -0.085 | 0.002 | 1.0e-200 | 1,802.0 |
| rs4509570 | C | G | 0.720 | -0.048 | 0.002 | 9.3e-94 | 437.4 |
| rs4845626 | T | G | 0.187 | 0.052 | 0.003 | 1.4e-85 | 398.5 |
| rs4845663 | T | C | 0.592 | -0.013 | 0.002 | 4.5e-10 | 40.3 |
| rs55676222 | A | T | 0.914 | 0.066 | 0.004 | 2.0e-71 | 313.4 |
| rs56100876 | A | G | 0.018 | -0.106 | 0.008 | 5.4e-39 | 172.5 |
| rs61806853 | T | C | 0.962 | 0.044 | 0.005 | 3.8e-20 | 84.0 |
| rs61811421 | T | C | 0.259 | 0.038 | 0.002 | 2.0e-53 | 245.4 |
| rs67156297 | A | G | 0.250 | 0.031 | 0.002 | 2.7e-43 | 197.3 |
| rs72698179 | A | C | 0.037 | 0.056 | 0.006 | 1.5e-18 | 77.6 |
| rs7523010 | A | T | 0.249 | 0.024 | 0.003 | 1.2e-19 | 85.2 |
| rs7525477 | A | G | 0.480 | 0.029 | 0.002 | 2.6e-43 | 197.3 |
| rs75456865 | A | T | 0.978 | -0.044 | 0.005 | 6.9e-17 | 69.5 |
| rs76289529 | T | C | 0.033 | -0.052 | 0.006 | 6.4e-20 | 83.5 |
| rs77994623 | T | C | 0.136 | 0.046 | 0.003 | 1.6e-61 | 284.0 |
| rs78739139 | A | G | 0.062 | -0.050 | 0.005 | 1.0e-27 | 118.1 |
| rs79438587 | T | C | 0.160 | -0.018 | 0.003 | 1.4e-10 | 39.8 |
| rs79505546 | T | C | 0.011 | -0.059 | 0.009 | 3.9e-11 | 43.3 |
| rs79778789 | A | G | 0.986 | 0.053 | 0.008 | 4.4e-11 | 43.9 |
| rs79794939 | T | C | 0.073 | 0.035 | 0.004 | 9.2e-20 | 81.5 |
| rs8192484 | A | T | 0.973 | -0.041 | 0.007 | 1.3e-08 | 32.6 |
| rs9427092 | T | C | 0.817 | -0.029 | 0.002 | 1.8e-30 | 136.4 |
EA, effect allele. OA, other allele. EAF, effect allele frequency. SE, standard error