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. 2023 Jun 5;13:1156743. doi: 10.3389/fonc.2023.1156743

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Copyright © 2023 Pearce, Akarca, De Maeyer, Kostina, Huebner, Sivakumar, Karasaki, Shah, Janes, McGranahan, Reddy, Akbar, Moore, Marafioti, Swanton and Hynds

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B lymphoproliferations arising from different primary tumour regions show distinct immunoglobulin light chain rearrangements. (A) Immunohistochemical staining with anti-IgK (left) and anti-IgL (right) antibodies in the CRUK0810 R8, CRUK0941 R1 and CRUK1054 R5 xenografts. Scale bars = 1.0 mm. (B) Flow cytometry analysis of IgK and IgL expression within CD45+ cells that were also positive for either CD19 or CD20. (C) PCR analysis of rearrangements to immunoglobulin light chain loci, including those to the kappa deleting element (Kde), in cases where multiple lymphoproliferations arose in xenografts of distinct tumor regions.