Table 1.

Exosome crosstalk between B cells and other cells.

Other cell-derived exosomes act on B cells
Tumor type	Source	In vivo/in vitro	Action type/specific axis	Effect	Effects on tumors	Ref.
——	DC	In vivo	Stimulate B cell proliferation	CD8 + T cell response was induced	Kill cancer cells	(68)
——	Mature DC	In vivo	Binds to B cell receptors	Induces T cell proliferation	——	(69)
——	T cells	In vivo	——	Promote B cell proliferation and differentiation	——	(70)
——	Mesenchymal cells	——	TGF-β1 is produced	Regulates B cell proliferation and survival	——	(71)
HCC	Tumor cells	In vitro	HMGB1-TLR2/4-MAPK	Induction of B cells to become TIM-1Breg, impairing CD 8T cell function	Promote HCC progression	(72)
HNSCC	plasma	In vitro	——	Inhibits the proliferation, viability and function of B cells	Helps immune escape	(73)
B-cell-derived exosomes act on other cells
Tumor type	Target cells	In vivo/in vitro	Action type/specific axis	Effect	Effects on tumors	Ref.
Ovarian cancer	cancer cell	In vitro	miR-330-3p/JAM2 axis	Inducing mesenchymal procedures	Promote the growth of cancer cells	(74)
——	T cell	In vivo	Rab27a expression is up-regulated	Impaired CD8T cell response	Promote tumor survival	(75)
——	T cell	In vivo	C3 fragments are deposited on the surface of the cell membrane	Enhance T cell response, conducive to the development of immune response	Inhibits tumors	(76)
——	Macrophages	In vivo	Enhances lipopolysaccharide stimulation	Reduces the release of TNFα	Promote tumor survival	(77)