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. 2022 Mar 28;53(8):3426–3436. doi: 10.1017/S0033291721005493

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© The Author(s) 2022

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

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Fig. 3. — (a) Results of the whole-brain voxelwise mixed model of the reward anticipation phase. Left: significant three-way interaction of group × depletion condition × reward level within the left ventral anterior insula (x = −39). Right: significant three-way interaction of intervention × group × reward level within the right ventral anterior insula (x = 39). FWE corrected with p < 0.05. (b) Mean activation in each group in each reward level (β estimates plus a smooth regression line) in the left and right ventral anterior insula during the reward anticipation phase at both time points (ATD and sham depletion). DEPL = acute tryptophan depletion; SHAM = sham depletion; recAN = individuals with a history of AN; HC = healthy control participants; BOLD = blood oxygen level dependent.