Skip to main content
. 2022 Oct 17;31(6):1688–1704. doi: 10.1016/j.ymthe.2022.10.005

Figure 2.

Figure 2

Heart function and cardiac histological changes of cA-circSlc8a1-transgenic mice evaluated by echocardiography and staining

(A) The representative echocardiography of cA-circSlc8a1-transgenic mice at different ages. (B) Echocardiography of cA-circSlc8a1(+) mice showed reduced left ventricular ejection fraction (LVEF) compared with the litter-matched negative mice. ∗∗p < 0.01 versus negative. (C) Echocardiography of cA-circSlc8a1(+) mice showed reduced left ventricular fractional shortening (LVFS) compared with the litter-matched negative mice. ∗∗p < 0.01 versus negative. (D) Echocardiography of cA-circSlc8a1(+) mice showed reduced left ventricular pressure (dp/dt) compared with the litter-matched negative mice. ∗∗p < 0.01 versus negative. (E) Representative photographs of Masson trichrome staining and Sirius red staining showing significant development of cardiac fibrosis in cA-circSlc8a1(+) mice after age 12 months. H&E staining and WGA staining showed development of cardiac hypertrophy in cA-circSlc8a1(+) mice as early as under age 6 months.