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. 2022 Oct 17;31(6):1688–1704. doi: 10.1016/j.ymthe.2022.10.005

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circSlc8a1 protected the heart function via binding to mitochondrial proteins

(A) Mass spectrophotometry analysis showed that 36% of the total proteins (types) precipitated by the circSlc8a1 probe were mitochondrial proteins. (B) Subcellular localization of circSlc8a1 in the cytosol (excluding mitochondria), mitochondria, and nuclei in the mouse heart tissues. n = 6; ∗∗p < 0.01 versus circNeg. (C) Subcellular localization of circSlc8a1 in the cytosol (excluding mitochondria), mitochondria, and nuclei in HL-1 cells. n = 4; ∗∗p < 0.01 versus vector. (D) The purity of mitochondrial fraction in the mouse heart tissue was validated by examining GAPDH and the mitochondrially encoded ATP8 (MT-ATP8). n = 5. (E) The purity of mitochondrial fraction in the HL-1 cells was validated by examining GAPDH and the mitochondriallly encoded ATP8 (MT-ATP8). n = 5. (F) Representative photographs of the co-localization of circSlc8a1 and the mitochondrial marker (VDAC) in HL-1 cells. (G) Representative photographs of the co-localization of circSlc8a1 and the mitochondrial marker (VDAC) in negative and cA-circSlc8a1(+) mouse heart tissue.