Table 3.
Clinical and demographic characteristics of patients with and without cognitive impairment.
|
All patients (n = 22) |
MoCA <26 (n = 9) |
MoCA ≥ 26 (n = 13) |
p-value | |
|---|---|---|---|---|
| Age (years) | 68 (58–71) | 69 (63–71) | 63 (44–70) | 0.22 |
| > 65 years, n (%) | 12 (54) | 6 (66.6) | 6 (46) | 0.41 |
| Male, n (%) | 15 (68) | 5 (55.5) | 10 (76.9) | 0.48 |
| BMI (kg/m2) | 32 (27–38) | 33 (30–38) | 32 (27–33) | 0.48 |
| Comorbidities, n (%) | ||||
| Obesity | 14 (59) | 7 (77.7) | 7 (53.8) | 0.38 |
| Smoking | 13 (68) | 6 (66.7) | 7 (53.8) | 0.67 |
| Diabetes | 4 (18) | 0 (0) | 4 (30) | 0.98 |
| Hypertensión | 9 (41) | 3 (33) | 6 (46) | 0.67 |
| Charlson score | 3 (1–4) | 3 (2–4) | 2 (1–3) | 0.19 |
| Vaccinated, n (%) | 18 (81) | 7 (77.7) | 11 (84.6) | 0.6 |
| Ferritin (ng/L) | 1406 (633–1988) | 1066 (517–1582) | 1406 (934–2090) | 0.42 |
| Apache II | 18.5 (14–21) | 21 (19–25) | 16 (13–19) | 0.0032 |
| SOFA on admission | 8 (6–8) | 8 (8–9) | 6 (4–8) | 0.026 |
| Severe ARDS, n (%) | 6 (27) | 4 (44.4) | 2 (15.3) | 0.18 |
| VAP, n (%) | 14 (63.6) | 7 (77.7) | 7 (53.8) | 0.38 |
| Duration of MV (days) | 37 (12–46) | 46 (40–54) | 30 (7–37) | 0.0082 |
| Prone position, n (%) | 9 (41) | 6 (66.7) | 3 (23) | 0.079 |
| Vasopressors use n (%) | 20 (91) | 9 (100) | 11 (84.6) | 0.49 |
| Tracheostomy, n (%) | 15 (68) | 8 (88.9) | 7 (53.8) | 0.16 |
| Days on NMB | 4.5 (3–14) | 9 (3–22) | 7 (4–14) | 0.32 |
| Days on midazolam | 12 (6–21) | 20 (6–26) | 10 (4–13) | 0.10 |
| Midazolam (mg/Kg) | 61 (23–101) | 93.57 (87–129.6) | 39.2 (21.4–62.7) | 0.02 |
| MP pulses, n (%) | 8 (36.3) | 2 (22) | 6 (46) | 0.38 |
| Delirium, n (%) | 17 (77.2) | 7 (77.7) | 10 (76.9) | 1 |
| DFD in 28 days | 22 (11–26) | 16 (0–23) | 24 (20–27) | 0.08 |
| Delirium duration (days) | 5 (1–14) | 13 (9–15) | 1 (4–6) | 0.14 |
| ICU LOS (days) | 43 (21–56) | 56 (48–63) | 41 (16–44) | 0.03 |
| Hospital LOS (days) | 60 (43–63) | 60 (22–61) | 58 (55–64.5) | 0.34 |
| Days on vasopressors | 9 (4–13) | 12 (9–19) | 6 (1–13) | 0.08 |
| Referral on hospital discharge, n (%) | ||||
| Home | 12 (54.5) | 1 (11) | 9 (82) | |
| Rehabilitation center | 10 (45.4) | 8 (88.9) | 2 (15.3) |
Data are shown as numbers (%), median [IQR]. Abbreviations: BMI: body mass index, SOFA sequential organ failure assessment, ARDS: acute respiratory distress syndrome, smokers: includes current and former smokers, VAP: ventilator-associated pneumonia, NMB: neuromuscular blockers, MP: methylprednisolone, DFD: Delirium free days LOS: length of stay.