Figure 8.

Ripasudil accelerates liver repopulation of Fah^−/− mice

(A) Dpp4 and Fah costaining of Fah^−/− mouse liver sections 2, 3, and 4 weeks after wild-type hepatocyte transplantation under treatment with ripasudil or vehicle control. The inset in (A) is a higher-magnification view of the area in the red box of each image. (B) The percentage of liver engraftment at 2, 3, and 4 weeks was quantified. (C and D) Serum analysis of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in Fah^−/− mice 4 weeks after hepatocyte transplantation under treatment with ripasudil or vehicle control. The scale bars represent 250 μM in (A). Data are shown as the means ± SEMs. ∗∗p < 0.01.