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. 2023 May 12;31(6):1661–1674. doi: 10.1016/j.ymthe.2023.05.006

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© 2023 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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MSH3 silencing with di-valent siMSH3_1000 or si-MSH3_1468 does not affect microsatellite instability

Microsatellite instability (MSI) traces of the (A) mBAT 24, (C) mBAT 26, or (E) mBAT 64 mononucleotide repeat locus. MSI was compared between PBS, NTC, siMSH3_1000, and siMSH3_1468. MSI quantitation at the (B) mBAT 24, (D) mBAT 26, or (F) mBAT 64 loci. Traces were analyzed with Thermo Fisher Cloud PeakScanner. Primers are reported in the materials and methods. MSI is compared with NTC (one-way ANOVA). n = 4–6 mice per condition. Data shown are the mean ± standard deviation.