Figure 6.

MSH3 silencing does not alter expression of additional mismatch repair genes

The mRNA expression of MSH3, MSH2, MSH6, MLH1, MLH3, PMS1, and PMS2 was measured by QuantiGene Singleplex assay on the medial cortex of the 4-month-treated BAC-CAG mice whose data are shown in Figure 4. Each data point is the average of three technical replicates from one mouse. Each siMSH3_1000-treated gene expression column is normalized to the NTC mouse for that gene (one-way ANOVA treatment with Dunnett’s multiple comparison test, ∗p < 0.05). Data shown are the mean ± range.