. 2023 Apr 17;31(6):1807–1828. doi: 10.1016/j.ymthe.2023.04.007

Table 1.

Morphometric and echocardiographic characteristics of WT and miRNA-216a KO mice subjected to 4 weeks of sham or TAC

	Sham		TAC
	WT	miR-216a KO	WT	miR-216a KO
N	6	10	8	3
TL (mm)	19.71 ± 0.46	19.58 ± 0.15	19.29 ± 0.42	19.32 ± 0.46
BW (g)	21.85 ± 1.50	21.97 ± 1.22	21.48 ± 1.56	21.93 ± 1.10
HW (g)	0.12 ± 0.009	0.15 ± 0.01	0.21 ± 0.02^a	0.19 ± 0.02^a
HW/BW	0.006 ± 0.0001	0.007 ± 0.0002	0.01 ± 0.0004^a	0.01 ± 0.0006^a
HW/TL (g/mm)	0.006 ± 0.0004	0.008 ± 0.0004	0.01 ± 0.001^a	0.01 ± 0.0001^a
LV mass (mg)	90.01 ± 4.28	93.29 ± 0.61	166.43 ± 14.84^a	214.36 ± 42.16^a
LV mass/BW (mg/g)	4.07 ± 0.39	4.06 ± 0.20	7.18 ± 0.34^a	10.0 ± 2.45^a^,^b
LV mass/TL (mg/mm)	4.48 ± 0.39	4.47 ± 0.27	7.98 ± 0.63^a	11.05 ± 2.007^a^,^b
IVSd (mm)	0.96 ± 0.04	0.80 ± 0.04^b	1.18 ± 0.05^a	1.82 ± 0.18^a^,^b
IVSs (mm)	1.40 ± 0.05	1.21 ± 0.05^b	1.49 ± 0.03	1.98 ± 0.15^a^,^b
LVIDd (mm)	3.57 ± 0.06	3.94 ± 0.12	3.73 ± 0.15	3.06 ± 0.23^a^,^b
LVIDs (mm)	2.11 ± 0.08	2.47 ± 0.14^a	2.38 ± 0.09^a	2.79 ± 0.22^b
LVPWd (mm)	0.81 ± 0.03	0.83 ± 0.05	1.07 ± 0.03^a	1.67 ± 0.14^a^,^b
LVPWs (mm)	1.28 ± 0.04	1.08 ± 0.05	1.32 ± 0.05^a	1.78 ± 0.16^a^,^b
FS (%)	40.96 ± 1.82	30.24 ± 1.66^b	32.55 ± 1.23^a	14.70 ± 2.69^a
EF (%)	72.42 ± 2.13	57.87 ± 2.60^b	61.08 ± 3.38^a	32.45 ± 5.55^a

Data are expressed as means ± SEM. BW, body weight; LV, left ventricular; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVPWd, left ventricular posterior wall thickness at end-diastole; LVPWs, left ventricular posterior wall thickness at end-systole; FS, fractional shortening; EF, ejection fraction.

Indicates p < 0.05 vs. WT sham group.

Indicates p < 0.05 vs. experimental group.