Table 2.

Morphometric and echocardiographic characteristics of WT and miRNA-216a KO mice subjected to 4 weeks of sham or MI

	Sham		TAC
	WT	miR-216a KO	WT	miR-216a KO
N	6	11	8	12
TL (mm)	19.85 ± 0.10	19.38 ± 0.27	19.40 ± 0.35	19.33 ± 0.31
BW (g)	22.18 ± 1.49	28.45 ± 0.59b	20.25 ± 1.26	23.73 ± 0.87a
HW (g)	0.14 ± 0.01	0.20 ± 0.01	0.18 ± 0.02	0.25 ± 0.03
HW/BW	0.006 ± 0.0005	0.007 ± 0.0003	0.009 ± 0.001	0.010 ± 0.002
HW/TL (g/mm)	0.007 ± 0.0004	0.011 ± 0.0006b	0.009 ± 0.0008	0.013 ± 0.0014b
LV mass (mg)	97.48 ± 6.84	112.31 ± 4.01	112.04 ± 6.98	106.78 ± 6.15
LV mass/BW (mg/g)	4.36 ± 0.53	3.92 ± 0.19	5.81 ± 0.53	4.56 ± 0.33
LV mass/TL (mg/mm)	0.22 ± 0.03	0.2 ± 0.01	0.3 ± 0.03	0.24 ± 0.02
IVSd (mm)	0.89 ± 0.06	0.86 ± 0.03	0.72 ± 0.12	0.46 ± 0.10a
IVSs (mm)	1.40 ± 0.07	1.27 ± 0.03	0.99 ± 0.15	0.57 ± 0.12a,b
LVIDd (mm)	3.79 ± 0.14	4.22 ± 0.07	4.48 ± 0.30	5.32 ± 0.21b
LVIDs (mm)	2.19 ± 0.13	2.90 ± 0.07b	3.39 ± 0.33a	4.53 ± 0.31a,b
LVPWd (mm)	0.87 ± 0.04	0.86 ± 0.04	0.89 ± 0.10	0.78 ± 0.05
LVPWs (mm)	1.45 ± 1.89	1.29 ± 0.04	1.22 ± 0.10	1.06 ± 0.08
FS (%)	42.37 ± 1.89	31.33 ± 0.87b	25.20 ± 1.26a	15.94 ± 2.50a,b
EF (%)	73.90 ± 2.10	59.44 ± 1.30b	49.49 ± 4.17a	32.44 ± 4.80a,b

Data are expressed as means ± SEM. BW, body weight; LV, left ventricular; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVPWd, left ventricular posterior wall thickness at end-diastole; LVPWs, left ventricular posterior wall thickness at end-systole; FS, fractional shortening; EF, ejection fraction.

^aIndicates p < 0.05 vs. WT-sham group.

^bIndicates p < 0.05 vs. experimental group.