Figure 6.

Mouse and human HCC have similar gene expression profiles based on miR-22 levels revealing human relevance of the findings

(A) Fifteen common pathways were identified by comparing miR-22 Hi (high, n = 89) vs. miR-22 Lo (low, n = 92) human HCC and miR-22 treated vs. untreated mouse HCC. (B) The fold changes of RA and IL17 signaling-related genes in miR-22 Hi vs. miR-22 Lo human HCC. (C) The levels of miR-22 in human HCC vs. normal livers and different stages of HCC. The numbers in parentheses are case numbers. Data were shown with medium ±5 to 95 percentiles. (D) Kaplan-Meier survival curves of HCC patients with high and low miR-22 levels based on TCGA LIHC. p values were calculated by the log rank test. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 by unpaired two-tailed Student’s t test (B and C).