Table 5.

circRNAs associated with the inflammatory diseases that can potentially lead to cancer

circRNA	Inflammatory disease	Inflammatory/relative cell(s) response	Proposed mechanism	Potential-associated malignancy	Ref.
circZC3H4	silicosis	pulmonary macrophage activation	increasing ZC3H4 by miR-212 sponging	lung carcinoma	210
circHECTD1	silicosis	macrophage activation and fibroblast proliferation	balancing M1/M2 macrophages by ZC3H12A binding	lung carcinoma	189
circ-0003528	bronchitis	macrophage polarization	increasing CTLA4 by miR-224-5p, miR-324-5p and miR-488-5p sponging	lung carcinoma	211
circATRNL1	ovarian endometriosis	promoting proliferation, migration, and invasion of Ishikawa cells	increasing YAP1 by miR-141-3p and miR-200a-3p sponging	ovarian carcinoma	212
circ_0088194	rheumatoid arthritis	promoting the invasion and migration of rheumatoid arthritis fibroblast-like synoviocytes	increasing MMP2 by miR-766-3p sponging	osteosarcoma	213
circRNA.33186	osteoarthritis	promoting proliferation and inhibit apoptosis of IL-1β-treated chondrocytes	increasing MMP-13 by miR-127-5p sponging	osteosarcoma	214
circFBXW4	hepatic fibrosis	inhibiting activation, proliferation and induced apoptosis of hepatic stellate cells	increasing FBXW7 by miR-18b-3p sponging	liver cancer	215
circ_103765	Crohn’s disease	promoting proliferation and apoptosis of human intestinal epithelial cell	increasing DLL4 by miR-30 family sponging	colorectal carcinoma	216
circHECTD1	ulcerative colitis	promoting enterocyte autophagy	increasing HuR by miR-182-5p sponging	colorectal carcinoma	217
circ_0089172	Hashimoto’s thyroiditis	N/A	increasing IL-23R by miR-125a-3p sponging	lymphoid tissue lymphoma	218