Table 3.
Ventilation, oxygenation, and anthropometric data in infants with surgical NEC classified by BPD
| Variable | N | Overall n (%)/median (IQR) N = 92 | Non/mild BPD n (%)/median (IQR) N = 21 | Moderate-to-severe BPD n (%)/median (IQR) N = 71 | p-Value |
|---|---|---|---|---|---|
| Day 7 FiO2 | 51 | 28 (21, 40) | 23.0 (21.0, 46.0) | 29.0 (22.0, 36.0) | 0.58 |
| Day 7 ventilation mode | 52 | 0.02 | |||
| Room air | 4(7.7) | 3(21.4) | 1 (2.6) | ||
| Intubated | 35 (67.3) | 6 (42.9) | 29 (76.3) | ||
| CPAP | 5 (9.6) | 3(21.4) | 2 (5.3) | ||
| HFNC | 5 (9.6) | 2 (14.3) | 3 (7.9) | ||
| Noninvasive (NIMV) | 3 (5.8) | 0 (0.00) | 3 (7.9) | ||
| Mode of ventilation outborn | 36 | 1 | |||
| Intubated | 35 (97.2) | 4 (100.0) | 31 (96.9) | ||
| NIMV | 1(2.8) | 0 (0.00) | 1 (3.1) | ||
| FiO2 admission outborn | 37 | 44 (29, 70) | 47.5 (36, 77.5) | 44.0 (28.0, 70.0) | 0.47 |
| Invasive ventilation duration before NEC | 60 | 7 (3, 13.5) | 1.5 (1,4) | 7.5 (4, 15) | 0.003 |
| Non-invasive duration before NEC | 32 | 8 (3.5, 15) | 5.5 (2, 8) | 9.5 (4, 17) | 0.10 |
| FiO2 7 d before NEC | 31 | 25 (21, 40) | 25.5 (21, 50) | 25.0 (21.0, 38.0) | 0.97 |
| Ventilation mode 2 weeks after NEC | 78 | <.001 | |||
| Room air | 12 (15.4) | 9 (64.3) | 3 (4.7) | ||
| Intubated | 54 (69.2) | 2(14.3) | 52 (81.3) | ||
| CPAP | 5 (6.4) | 1 (7.1) | 4(6.3) | ||
| HFNC | 7 (9.0) | 2(14.3) | 5 (7.8) | ||
| Invasive vent duration after NEC (d) | 88 | 22 (8, 56) | 6 (2, 13) | 40.5 (12, 59) | <.001 |
| Noninvasive duration after NEC | 73 | 41 (11, 71) | 5 (4, 8.5) | 51.0 (25.0, 93.0) | <.001 |
| FiO2 after 2 weeks of NEC | 79 | 28 (21, 36) | 21.0 (21.0, 21.0) | 30.0 (24.0, 36.0) | 0.001 |
| Home O2 | 53 | 16 (30.2) | 0 (0.00) | 16 (38.1) | 0.02 |
| Weight at 36 weeks (g) | 82 | 2,085 (1,800, 2,335) | 2,332.0 (2,200.0, 2,445.0) | 2,030.0 (1,800.0, 2,250.0) | 0.03 |
| Length at 36 weeks (cm) | 81 | 42 (39, 44) | 45.0 (43.0, 48.4) | 41.3 (39.0, 43.8) | 0.002 |
| Weight for length | 81 | 5 (4.5, 5.5) | 5.1 (4.5, 5.4) | 4.9 (4.5, 5.5) | 0.68 |
| Weight centile at 36 weeks | 82 | 8 (2, 19) | 18.0 (11.0, 26.0) | 6 (2, 18) | 0.06 |
| Length centile at 36 weeks | 81 | 2 (0, 10) | 19.0 (4.0, 69.0) | 2 (0, 9.5) | 0.02 |
Abbreviations: CPAP, continuous positive airway pressure; fiO2, fraction of inspired oxygen; HFNC, high flow nasal cannula; IQR, interquartile range.
Note: Categorical variables are presented as count (percentage). Continuous variables are presented as mean (standard deviation) and, if not normally distributed, as median with interquartile range. Continuous measures’ statistical associations with lung injury were evaluated with the Kruskal–Wallis test. Differences in categorical measures’ associations were tested using the Chi-square test when expected cell counts were adequate, otherwise Fisher–Freeman–Halton exact tests were used with low expected cell counts. Fenton chart used for anthropometric measurement. Bold values are statistically significant.