Figure 1.

The potential protective effects of coenzyme Q₁₀ against COVID-19: CoQ₁₀ is an essential co-factor in electron transport chain of the phosphorylation oxidative system. Because of its lipophilic anti-oxidant power, it has potential ability for regenerating the VitE and VitC. Moreover, the anti-angiotensin 2 effect of CoQ₁₀ improve the RAS activity which is upregulated in COVID-19. The anti-apoptotic, immunomodulatory, and anti-inflammatory effects of CoQ₁₀ have been also confirmed through reducing TNF-a, IL-6, and CRP. The cardiovascular protective effects of CoQ₁₀ have been also determined, such as improving viral myocarditis and using in drug induced cardiotoxicity. Moreover, CoQ₁₀ has some protective effects in CNS. It can pass easily through BBB, reduce oxidative stress, and modulate the immunologic reaction. BBB: Brain blood barrier.