Figure 4.

The effective role of CoQ₁₀ against severe oxidative stress by improving the mitochondrial dysfunction: One of the most crucial elements of sepsis infections is severe oxidative stress which is caused by mitochondrial dysfunction leading to decreasing IL-10 and VCAM. During a septic shock, a condition in which the level of CoQ₁₀ is decreased and it accompanies by increasing IL-6 and decreasing LDL (plasma carrier of CoQ₁₀), optimal oxygenation and as a result making proper hemodynamic condition, are supposed to improving the mitochondrial dysfunction. Although CoQ₁₀ has proven benefits in suppressing the production of ROS, raising the cellular metabolism, and sustaining the function of Na/K ATPas, the supplementation with CoQ₁₀ could not solely benefit critically for the ill advanced patients. ROS: Reactive oxygen species