Table 2. Various components of the blood of the animals were administrated with the plain extract of E. purpurea and EP-Eudragit RS100 NPs .
| Variables | Groups | ||||
| Control |
Plain extract of
E. purpurea
(30 mg/kg) |
Plain extract of
E. purpurea
(100 mg/kg) |
F1
(30 mg/kg) |
F1
(100 mg/kg) |
|
| WBC ( × 103/μL) | 2.96 ± 0.40 | 4.67 ± 0.56 | 4.48 ± 0.30 | 4.99 ± 0.50 | 4.73 ± 0.86 |
| Lymph ( × 103/μL) | 1.48 ± 0.23 | 3.4 ± 0.50 | 3.01 ± 0.17 | 3.18 ± 0.32 | 3.23 ± 0.59 |
| Lymph (%) | 54.51 ± 3.15 | 69.15 ± 2.67 | 67.91 ± 3.11 | 63.88 ± 3.37 | 68.15 ± 2.69 |
| Mono ( × 103/μL) | 0.59 ± 0.06 | 0.83 ± 0.13 | 0.81 ± 0.09 | 1.11 ± 0.20 | 0.89 ± 0.28 |
| Mono (%) | 22.9 ± 1.69 | 17.03 ± 0.68 | 18.03 ± 1.45 | 22 ± 2.32 | 18 ± 2.61 |
| Neut ( × 103/μL) | 0.47 ± 0.11 | 0.45 ± 0.02 | 0.49 ± 0.10 | 0.62 ± 0.07 | 0.45 ± 0.01 |
| Neut (%) | 16.98 ± 1.79 | 10.56 ± 1.88 | 10.66 ± 1.51 | 12.6 ± 1.04 | 10.42 ± 1.50 |
| Eos ( × 103/μL) | 0.04 ± 0.02 | 0.03 ± 0.01 | 0.02 ± 0.00 | 0.02 ± 0.01 | 0.05 ± 0.01 |
| Eos (%) | 1.51 ± 0.40 | 0.95 ± 0.22 | 0.51 ± 0.06 | 0.46 ± 0.08 | 1.42 ± 0.37 |
| Baso ( × 103/μL) | 0 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.02 ± 0.01 |
| Baso (%) | 0.15 ± 0.03 | 0.18 ± 0.03 | 0.18 ± 0.03 | 0.18 ± 0.05 | 0.36 ± 0.13 |
| RBC ( × 103/μL) | 7.56 ± 0.23 | 7.77 ± 0.19 | 7.31 ± 0.23 | 7.85 ± 0.19 | 7.11 ± 0.14 |
| HGB (g/dL) | 12.91 ± 0.47 | 14.01 ± 0.40 | 12.85 ± 0.22 | 13.16 ± 0.19 | 12.1 ± 0.33 |
| HCT (%) | 44.11 ± 2.04 | 45.00 ± 1.16 | 41.85 ± 0.89 | 44.96 ± 0.64 | 41.12 ± 0.75 |
| MCV (fl) | 58.26 ± 0.90 | 57.85 ± 0.34 | 57.3 ± 0.75 | 57.3 ± 0.86 | 57.77 ± 0.30 |
| MCH (pg) | 17.06 ± 0.35 | 18.01 ± 0.11 | 17.6 ± 0.30 | 16.78 ± 0.28 | 17.02 ± 0.63 |
| MCHC (g/dL) | 29.31 ± 0.63 | 31.13 ± 0.25 | 30.71 ± 0.25 | 29.22 ± 0.32 | 29.47 ± 0.99 |
All values are given as mean ± SE in each group.
TNF-α: tumor necrosis factor-alpha, IL-1β: Interleukin 1 beta, WBC: white blood cell count, Lymph: Lymphocyte, Mono: monocyte, Neut: neutrophil, Eos: eosinophil, Baso: basophil, RBC: red blood cell count, HGB: hemoglobin, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration. F1 formulation represents EP-Eudragit RS100 NPs which were spray-dried using the mixture of extract:polymer (1:5) and dissolved in methanol at the final concentration of 10% w/v. F2 formulation represents EP-Eudragit RS100 NPs which were spray dried using the mixture of extract:polymer (1:5) and dissolved in methanol at the final concentration of 15% w/v.