Table 1.
Amino acid alignment of antigen orthologues between MVA and monkeypox virus
| Antigen | Virion form | kDa | Blast Amino acid | Functions in virus infection and replication | ||
|---|---|---|---|---|---|---|
| MVA | MPXV | |||||
| Accession No. U94848.1 |
Accession No. ON563414.3 |
Similarity(%) | Gap(%) | |||
| A27 | A29 | MV | 12.5 | 93.6 (103/110) | 0.0 (0/110) | Fusion protein, virus-cell attachment, virus-cell fusion, and virus release from cells |
| A33 | A35 | EV | 20.6 | 94.5 (171/181) | 0.0 (0/181) | Glycoprotein, an integral component of the membrane, lyses the EV membrane |
| B5 | B6 | EV | 35.1 | 96.2 (305/317) | 0.0 (0/317) | Complement control protein, MV wrapping, EV morphogenesis, and release of the virus from the cell |
| L1 | M1 | MV | 27.3 | 98.8 (247/250) | 0.0 (0/250) |
Myristylated MV surface membrane protein, cellular entry |
| H3 | H3 | MV | 37.5 | 94.4 (306/324) | 0.0 (0/324) | Immunodominant MV protein, attachment of poxviruses to cells, viral morphogenesis |
| I1 | I1 | MV | 35.9 | 98.7 (308/312) | 0.0 (0/312) | DNA (telomere)-binding core protein |
EV: enveloped virion; MV: mature virion.