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. 2023 Jun 19;16:140. doi: 10.1186/s12920-023-01576-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Landscape of overall analysis characteristics of eccDNA. A Distribution landscape of eccDNA in chromosome source. B Length distribution of eccDNA shows peaks at 200 -600 bases. C The sites in the genome that give rise to small eccDNA are enriched relative to random expectation in genic sites, The top three are RepeatMasker, ExonPlus, Introns. D The significantly amplified genes on OC were obtained by GEPIA2. E Intersection of eccDNA gene and OV amplified gene