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. 2023 Apr 11;12(11):12553–12568. doi: 10.1002/cam4.5894

FIGURE 6.

FIGURE 6

CircFAM114A2 suppresses HCC progression through miR‐630/HHIP axis. (A) Relative expression of miR‐630 were detected by qRT‐PCR in circFAM114A2 silenced or overexpressed cells. (B) Relative expression of HHIP mRNA in miR‐630 overexpressed cells. (C) The silenced efficiency of HHIP was detected by qRT‐PCR. (D) EdU assays were used to evaluate cell proliferation after co‐transfection with circFAM114A2 overexpression plasmid and HHIP siRNA. Scale bars, 200 μm. (E) CCK‐8 assays were used to evaluate cell viability after co‐transfection. (F) EdU assays were used to evaluate cell proliferation after co‐transfection with circFAM114A2 overexpression plasmid and miR‐630 mimic. Scale bars, 200 μm. (G) CCK‐8 assays were used to evaluate cell viability after co‐transfection. (H) IHC analysis of the expression of HHIP. The figures were imaged at 100× and 400× magnification. Scale bar, 100 μm and 20 μm. **p < 0.01.