. 2023 Apr 16;12(11):12234–12252. doi: 10.1002/cam4.5918

TABLE 5.

Prognostic models developed from the combination of several circulating factors.

Initial models (n = 51)	Univariate Cox		Multivariate Cox ^a		Multivariate Cox ^b
Initial models (n = 51)	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
PFS score (continuous)	2.72 (1.356–5.449)	0.005	2.17 (0.923–5.112)	0.076	2.67 (1.282–5.553)	0.009
PFS score (categorized high vs. low)	2.77 (1.358–5.665)	0.005	1.30 (0.591–2.848)	0.517	2.55 (1.239–5.249)	0.011
OS score (continuous)	2.72 (1.556–4.745)	<0.001	2.47 (1.306–4.653)	0.005	3.40 (1.860–6.220)	<0.001
OS score (categorized high vs. low)	3.92 (1.722–8.930)	0.001	2.06 (0.851–4.979)	0.109	5.29 (2.154–12.988)	<0.001

Treated models (n = 29)	Univariate Cox		Multivariate Cox ^a		Multivariate Cox ^b
Treated models (n = 29)	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
PFS score ^c (continuous)	1.849 (1.242–2.752)	0.002	1.272 (0.821–1.970)	0.282	1.449 (0.938–2.238)	0.094
PFS score ^c (categorized high vs. low)	4.420 (1.672–11.685)	0.003	1.250 (0.424–3.685)	0.685	1.452 (0.478–4.404)	0.510
OS score (continuous)	2.72 (1.451–5.091)	0.002	1.43 (0.685–2.989)	0.341	1.87 (0.938–3.717)	0.075
OS score (categorized high vs. low)	3.21 (1.115–9.241)	0.031	1.61 (0.491–5.294)	0.431	2.77 (0.883–8.711)	0.081

Abbreviations: OS, overall survival; PFS, progress‐free survival.

^{^a}

Adjusted for DCB.

^{^b}

Adjusted for response.

^{^c}

Only change rate of IL‐6 was in this model and categorized.