Fig. 1.

(a) Schematic of the optical probe and the locations of the bilateral optical measurements. The optical probe comprised 4 source-detector separations (SDS) for frequency-domain diffuse optical specotrscopy (FD-DOS, 1.5, 2.0, 2.5, 3.0 cm), a single SDS for diffuse correlation spectorscopy (DCS, 2.5 cm), and a single SDS for broadband DOS (bDOS, 3.0 cm). Mild-to-moderate focal contusion traumatic brain injury (TBI) was induced using a controlled cortical impact device in adult-aged swine (the skull and dura were permanently removed at the injury location). (b) Timeline of the study’s pre- and post-injury bilateral optical measurements. (c) Image of the instrument showing the commercial MetaOx (which combines FD-DOS and DCS), and our lab built bDOS instrument.