| AMG-228 |
Amgen |
Monospecific agonistic antibody |
Humanized IgG4 |
No |
Tetravalent |
| ASP1951 |
Astellas |
Hinge-stabilized monospecific agonistic antibody |
Fully human IgG4 |
No |
Tetravalent |
| BMS-986156 |
Bristol-Myers Squibb |
Monospecific agonistic antibody |
Fully human IgG1 |
Yes |
Not reported |
| GWN323 |
Novartis |
Monospecific agonistic antibody |
Humanized IgG1 |
Yes |
Bivalent |
| INCAGN1876 |
Incyte |
Monospecific agonistic antibody |
Humanized IgG1 |
Yes |
Not reported |
| MK-1248 |
Merck |
Monospecific agonistic antibody |
Humanized IgG4 |
No |
Bivalent |
| MK-4166 |
Merck |
Monospecific agonistic antibody |
Humanized IgG1 |
Yes |
Bivalent |
| REGN6569 |
Regeneron |
Monospecific agonistic antibody |
Fully human IgG1 |
Yes |
Not reported |
| TRX518 |
Leap Therapeutics |
Monospecific agonistic antibody |
Fully humanized aglycosylated IgG1κ agonistic |
No |
Bivalent |
| Undisclosed |
Abbvie |
Anti-PD-1–GITR-L bispecific agonistic antibody |
Humanized IgG1 with inert Fc |
No |
Trivalent |
|
Co-stimulatory GITR ligand
|
| MEDI1873 |
AstraZeneca |
Hexameric GITRL fusion protein (GITRL FP) comprising 2 GITRL ECD trimers and IgG1 Fc linked by isoleucine zipper trimerization domain |
Fully human IgG1 |
Yes |
Hexavalent |
| HERA-GITRL |
Apogenix |
Two trivalent single-chain GITRL binding domain (scGITRL-RBD) fused to IgG1 (Fc inert) dimerization scaffold |
Humanized IgG1 with inert Fc |
No |
Hexavalent |
