Figure 1.

Structures of RecQ5 genes and the encoded RecQ5 proteins. (a) Genomic structure of the RecQ5 gene and the exon uses of three RecQ5 mRNA isomers, RecQ5α, RecQ5β and RecQ5γ. (b) Schematic representation of three RecQ5 helicase isomers, RecQ5α, RecQ5β and RecQ5γ. The sizes of each protein are given on the right. The darkened areas indicate the locations of the helicase domains shared by the RecQ helicase family. The hatched areas indicate the extended homologous region to E.coli RecQ helicase. The regions indicated by bars indicate identical amino acid sequences among the three isoforms.