Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 3;136(8):886–898. doi: 10.1097/CM9.0000000000002642

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

PMC Copyright notice

The function of the ferroptosis mechanism is to balance oxidative damage and antioxidant defense. The mechanism of ferroptosis mainly involves two parts: oxidative damage and antioxidant defense. When the physiological state of the body changes and oxidative damage increases, ferroptosis and ferroptotic cell death are induced; in contrast, overexuberant antioxidant defense hinders the occurrence of ferroptosis. AA: Arachidonic acid; ACSL4: Acyl-CoA synthetase long-chain family member 4; AdA: Adrenic acid; BH4: Tetrahydrobiopterin; CoQ10: Coenzyme Q10; CoQ12: Coenzyme Q12; FSP1: Ferroptosis suppressor protein 1; GPX4: Glutathione peroxidase 4; GSH: Glutathione; iNOS: Inducible nitric oxide synthase; LOX: Lipoxygenase; NCOA4: Nuclear receptor coactivator 4; NO: Nitric oxide; NRF2: Nuclear factor erythroid 2-related factor 2; PE-AA: Arachidonic acid-phosphatidylethanolamine; PLOOHs: Phospholipid hydroperoxides; PUFA: Polyunsaturated fatty acid; ROS: Reactive oxygen species; SLC3A2: Solute carrier family 3 member 2; TF: Transferrin.