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. 2023 Apr 3;136(8):886–898. doi: 10.1097/CM9.0000000000002642

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Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Summary of the mechanisms related to ferroptosis in AML and ALL cells. The interaction of various molecules forms a network of molecular pathways related to ferroptosis. In AML cells, the upregulation of p53 expression by circKDM4C via hsa-let-7b-5p can reduce ferroptosis; also, APR-246 can target the mutant protein p53 in AML and promote the binding of mutant p53 to the target site of DNA to regain its transcriptional activity, the combination of APR-246 with ferroptosis inducers, or the inactivation of SLC7A11 has synergistic anti-leukemic activity in vitro; HMGB1 can regulate Erastin-induced ferroptosis through Ras-JNK/p38 signal pathway; additionally, some drugs or natural abstracts can also induce ferroptosis and help to fight AML. In ALL cells, the ubiquitination of PAQR3 by NRF2 can induce ferroptosis; RSL3 can induce ferroptosis by enhancing the production of ROS and this process can be blocked by LOX inhibitors or ferroptosis inhibitors; HD induces ferroptosis via reducing GSH and GPX4. ALL: Acute lymphoblastic leukemia; AML: Acute myeloid leukemia; AMPK: Adenosine monophosphate-activated protein kinase; APR-246: Eprenetapopt; ATLL: Adult T cell leukemia/lymphoma; ATPR: 4-Amino-2-trifluoromethyl-phenyl retinate; DFA: Deferoxamine; DHA: Dihydroartemisinin; DNA: Deoxyribonucleic acid; Fer-1: Ferrostain-1; GPX4: Glutathione peroxidase 4; GSH: Glutathione; HD: Hydnocarpin D; HMGB1: High mobility group protein 1; KDM4C: Lysine demethylase 4c; LOX: Lipoxygenases; NRF2: Nuclear factor erythroid 2-related factor 2; PAQR3: Progestin and adipoq receptor family member 3; Ras-JNK: Rat sarcoma-jun N-terminal kinase; ROS: Reactive oxygen species; RSL3: An inhibitor of glutathione peroxidase 4; SLC7A11: Solute carrier family 7 member 11; ub: Ubiquitination.