. 2023 Mar 15;34(6):955–968. doi: 10.1681/ASN.0000000000000117

Table 1.

Treatment effects and meta-regression parameters

Meta-Regression Parameters	Mean	SD	2.5th Percentile	25th Percentile	50th Percentile	75th Percentile	97.5th Percentile
Means and SDs of treatment effects on the three end points
Mean treatment effect on clinical end point (log HR)	−0.28	0.06	−0.40	−0.31	−0.27	−0.24	−0.16
SD for treatment effects on clinical end point (log HR)	0.28	0.07	0.16	0.23	0.27	0.32	0.42
Mean treatment effect on chronic slope (ml/min per 1.73 m² per yr)	0.63	0.13	0.38	0.54	0.63	0.72	0.89
SD for treatment effects on chronic slope (ml/min per 1.73 m² per yr)	0.65	0.13	0.43	0.56	0.64	0.73	0.93
Mean treatment effect on log UACR	−0.25	0.03	−0.30	−0.26	−0.25	−0.23	−0.19
SD for treatment effects on log UACR	0.15	0.03	0.10	0.13	0.15	0.17	0.21
Meta-regression relating treatment effects on CE jointly to treatment effects on chronic slope and UACR
Intercept	−0.03	0.09	−0.21	−0.09	−0.03	0.03	0.14
Coefficient of treatment effect on chronic slope	−0.41	0.12	−0.64	−0.49	−0.41	−0.34	−0.17
Coefficient of treatment effect on log UACR	−0.06	0.42	−0.90	−0.33	−0.06	0.21	0.77
RMSE	0.08	0.04	0.02	0.04	0.07	0.11	0.18
R²	0.88	0.13	0.54	0.83	0.93	0.98	1.00
Meta-regression relating treatment effects on chronic slope to treatment effects on UACR
Intercept	−0.04	0.25	−0.56	−0.20	−0.04	0.12	0.44
Coefficient of treatment effects on log UACR	−2.76	0.95	−4.71	−3.36	−2.74	−2.13	−0.96
R²	0.42	0.18	0.06	0.29	0.43	0.56	0.75

Shown are the mean and SDs as well as the 2.5th, 25th, 50th, 75th, and 97.5th percentiles of the posterior distributions of the treatment effects and the meta-regression parameters that define the joint model. The top panel summarizes the posterior distributions of the means and SDs of the treatment effects on the three end points. The middle panel summarizes the meta-regression coefficients for the joint meta-regression relating the treatment effects on the clinical end point to the treatment effects on both the chronic slope and UACR. The bottom panel summarizes the meta-regression coefficients relating the treatment effects on the chronic slope to the treatment effects on log UACR. HR, hazard ratio; UACR, urine albumin-to-creatinine ratio; RMSE, root mean square error; R², squared multiple correlation.