Table 1.
Demographic and clinical characteristics at diagnosis and clinical outcomes during follow-up (full-analysis population)
| Category | Overall | Adult | Pediatric |
|---|---|---|---|
| Age at diagnosis, No. (%) | 2439 (100) | 2299 (100) | 140 (100) |
| Mean, yrs (SD) | 41 (15) | 42 (14) | 13 (5) |
| Median, yrs (Q1, Q3) | 40 (29, 51) | 41 (31, 52) | 14 (10, 17) |
| Sex, No. (%) | 2439 (100) | 2299 (100) | 140 (100) |
| Female | 716 (29) | 674 (29) | 42 (30) |
| Male | 1723 (71) | 1625 (71) | 98 (70) |
| Ethnicity, No. (%) | 2439 (100) | 2299 (100) | 140 (100) |
| Asian | 228 (9) | 221 (10) | 7 (5) |
| Black | 32 (1) | 32 (1) | 0 (0) |
| Mixed | 14 (1) | 12 (1) | 2 (1) |
| Others | 36 (1) | 36 (2) | 0 (0) |
| White | 1885 (77) | 1768 (77) | 117 (84) |
| Not stated/missing | 244 (10) | 230 (10) | 14 (10) |
| BMI at diagnosis, No. (%) | 328 (13) | 313 (14) | 15 (11) |
| Mean, (SD) | 28 (8.5) | 29 (8.3) | 20 (7.9) |
| Median, (Q1, Q3) | 28 (24.1, 31.5) | 28 (24.2, 31.6) | 21 (16.2, 24.6) |
| Systolic BP at diagnosis, No. (%) | 299 (12) | 287 (12) | 12 (9) |
| Mean, (SD) | 138 (24) | 139 (24) | 118 (16) |
| Median, (Q1, Q3) | 137 (124, 152) | 138 (125, 153) | 113 (108, 127) |
| UPCR at diagnosis, No. (%) | 545 (22) | 526 (23) | 19 (14) |
| Mean, g/ga (SD) | 2.42 (3.57) | 2.41 (2.72) | 2.75 (2.78) |
| Median, g/g (Q1, Q3) | 1.51 (0.64, 3.13) | 1.51 (0.66, 3.09) | 2.10 (0.42, 4.04) |
| Nephrotic range proteinuria (>2.64 g/g) | 169 (7) | 161 (7) | 8 (6) |
| eGFR at diagnosis, No. (%) | 896 (37) | 880 (38) | 16 (11) |
| Mean, ml/min per 1.73 m2 (SD) | 55 (29) | 55 (29) | 78 (33) |
| Median, ml/min per 1.73 m2 (Q1, Q3) | 48 (32, 75) | 48 (32, 75) | 76 (53, 108) |
| CKD stage at diagnosis, No. (%) | 896 (37) | 880 (38) | 16 (11) |
| Stage 1 | 141 (16) | 136 (15) | 5 (31) |
| Stage 2 | 197 (22) | 191 (22) | 6 (38) |
| Stage 3 | 366 (41) | 361 (41) | 5 (31) |
| Stage 4 | 178 (20) | 178 (20) | 0 (0) |
| Stage 5 | 14 (2) | 14 (2) | 0 (0) |
| Length of follow-up, No. (%) | 2439 (100) | 2299 (100) | 140 (100) |
| Mean, yrs (SD) | 8.0 (7.3) | 7.7 (6.7) | 13.4 (12.4) |
| Median, yrs (Q1, Q3) | 5.9 (3.0, 10.5) | 5.8 (2.9, 10.1) | 8.2 (5.3, 17.0) |
| Kidney failure or death event, No. (%) | 2439 (100) | 2299 (100) | 140 (100) |
| Yes | 1210 (50) | 1156 (50) | 54 (39) |
| No | 1229 (50) | 1143 (50) | 86 (61) |
| First event, No. (%) | 1210 (50) | 1156 (50) | 54 (39) |
| Death | 21 (2) | 21 (2) | 0 (0) |
| Dialysis | 298 (25) | 277 (24) | 21 (39) |
| Transplant | 95 (8) | 86 (7) | 9 (17) |
| eGFR <15 ml/min per 1.73 m2 | 796 (66) | 772 (67) | 24 (44) |
| Time to first event, No. (%) | 1210 (50) | 1156 (50) | 54 (39) |
| Mean, yrs (SD) | 6.9 (7.1) | 6.6 (6.6) | 13.6 (12.3) |
| Median, yrs (Q1, Q3) | 4.5 (1.9, 9.6) | 4.3 (1.8, 9.3) | 10.2 (6.1, 16.1) |
| Age at first event, No. (%) | 1210 (50) | 1156 (50) | 54 (39) |
| Mean, yrs (SD) | 48 (15) | 49 (14) | 27 (10) |
| Median, yrs (Q1, Q3) | 48 (37, 58) | 49 (38, 59) | 24 (21, 32) |
| Survival rate, estimate (95% CI) | 2439 (100) | 2299 (100) | 140 (100) |
| 5-year | 0.72 (0.70 to 0.74) | 0.71 (0.69 to 0.73) | 0.91 (0.85 to 0.95) |
| 10-year | 0.54 (0.51 to 0.56) | 0.52 (0.50 to 0.55) | 0.76 (0.66 to 0.83) |
| 15-year | 0.40 (0.37 to 0.43) | 0.38 (0.36 to 0.41) | 0.62 (0.52 to 0.72) |
| 20-year | 0.29 (0.27 to 0.32) | 0.28 (0.25 to 0.31) | 0.52 (0.41 to 0.62) |
| Quartile survival estimate, yr (95% CI) | 2439 (100) | 2299 (100) | 140 (100) |
| 75% | 4.2 (3.9 to 4.7) | 4.0 (3.7 to 4.4) | 10.9 (7.3 to 12.4) |
| 50% | 11.4 (10.5 to 12.5) | 10.8 (10.0 to 12.0) | 21.6 (15.9 to NE) |
| 25% | 24.3 (21.8 to 25.8) | 22.9 (19.6 to 25.5) | NE (NE to NE) |
| eGFR slope, total, No. (%) | 1863 (76) | 1795 (78) | 68 (49) |
| Mean, ml/min per 1.73 m2/yr (SD) | −3.6 (8.2) | −3.7 (7.4) | −2.2 (19.6) |
| Median, ml/min per 1.73 m2/yr (Q1, Q3) | −2.4 (−5.7, −0.6) | −2.4 (−5.6, −0.6) | −3.6 (−8.3, −0.9) |
Q, quartile; BMI, body mass index; UPCR, urinary protein-creatinine ratio; CI, confidence interval; NE, not estimable.
a
0.0088 g/g=1 mg/mmol.