Table 3.
Estimated survival rate as a clinical outcome of proteinuria analysis in population 3
| Proteinuria Analysis Population 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline UPCR | <0.88 g/g | ≥0.88 g/g | |||||||||
| Total Time-Averaged Proteinuriaa Category | Overall | Combined | <0.44 g/g | 0.44 to <0.88 g/g | 0.88 to <1.76 g/g | ≥1.76 g/g | Combined | <0.44 g/g | 0.44 to <0.88 g/g | 0.88 to <1.76 g/g | ≥1.76 g/g |
| n=1153 | n=638 | n=302b | n=150b | n=141 | n=45 | n=515 | n=16b | n=77b | n=210 | n=212 | |
| % | Reference | 47.3%b | 23.5%b | 22.1% | 7.1% | Reference | 3.1%b | 15.0%b | 40.8% | 41.2% | |
| Survival rate, estimate (95% CI) | |||||||||||
| 5-yr | 0.72 (0.69 to 0.75) | 0.85 (0.81 to 0.88) | 0.90 (0.85 to 0.93)b | 0.94 (0.89 to 0.97)b | 0.75 (0.66 to 0.82) | 0.59 (0.41 to 0.72) | 0.58 (0.53 to 0.63) | 1.00 (1.00 to 1.00)b | 0.79 (0.66 to 0.87)b | 0.67 (0.59 to 0.73) | 0.40 (0.32 to 0.47) |
| 10-yr | 0.50 (0.45 to 0.54) | 0.64 (0.58 to 0.69) | 0.81 (0.74 to 0.87)b | 0.76 (0.62 to 0.86)b | 0.39 (0.28 to 0.50) | 0.26 (0.11 to 0.43) | 0.32 (0.26 to 0.39) | 0.50 (0.01 to 0.91)b | 0.60 (0.42 to 0.74)b | 0.35 (0.24 to 0.46) | 0.19 (0.11 to 0.27) |
| 15-yr | 0.31 (0.24 to 0.38) | 0.44 (0.33 to 0.54) | 0.75 (0.63 to 0.84)b | 0.41 (0.17 to 0.64)b | 0.20 (0.08 to 0.36) | 0.00 (0.00 to 0.00) | 0.16 (0.08 to 0.25) | NE (NE to NE)b | 0.00 (0.00 to 0.00)b | 0.15 (0.05 to 0.30) | 0.11 (0.04 to 0.22) |
UPCR, urinary protein-creatinine ratio; CI, confidence interval; NE, not estimable.
a
0.44 g/g=50 mg/mmol (approximately 0.5 g/d); 0.88 g/g=100 mg/mmol (approximately 1 g/d); 1.76 g/g=200 mg/mmol (approximately 2 g/d).
b
Represent patients who would be classified as low-risk disease progression (proteinuria of <1 g/d) as termed by Kidney Disease Improving Global Outcomes.11