Table 4.
Clinical outcomes of proteinuria analysis in population 4
| Proteinuria Analysis Population 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Time-Averaged Proteinuriaa Duration | 6–12 Months | 6–24 Months | |||||||
| Time-Averaged Proteinuria Category | Overall | Combined | <0.88 g/g | 0.88 to <1.76 g/g | ≥1.76 g/g | Combined | <0.88 g/g | 0.88 to <1.76 g/g | ≥1.76 g/g |
| Survival rate, estimate (95% CI) | n=535 | n=410 | n=125 | n=158 | n=127 | n=509 | n=152 | n=200 | n=157 |
| 5-yr | 0.71 (0.66 to 0.75) | 0.70 (0.64 to 0.75) | 0.83 (0.73 to 0.89) | 0.75 (0.66 to 0.82) | 0.50 (0.40 to 0.60) | 0.70 (0.65 to 0.75) | 0.88 (0.80 to 0.93) | 0.71 (0.62 to 0.78) | 0.53 (0.43 to 0.61) |
| 10-yr | 0.42 (0.35 to 0.50) | 0.38 (0.29 to 0.48) | 0.50 (0.32 to 0.66) | 0.44 (0.26 to 0.60) | 0.22 (0.11 to 0.36) | 0.43 (0.35 to 0.51) | 0.65 (0.49 to 0.77) | 0.45 (0.32 to 0.58) | 0.21 (0.11 to 0.34) |
| Kidney failure risk (10-year), HR (95% CI) | |||||||||
| Unadjusted | NA | NA | Reference | 1.38 (0.86 to 2.24) | 3.30 (2.10 to 5.19) | N/A | Reference | 2.03 (1.26 to 3.27) | 4.18 (2.64 to 6.63) |
| Adjusted | NA | NA | Reference | 1.43 (0.87 to 2.33) | 3.57 (2.24 to 5.70) | N/A | Reference | 2.01 (1.24 to 3.26) | 4.49 (2.80 to 7.21) |
| eGFR slope, 6–30 months (ml/min per 1.73 m2 per year) | n=501 | n=388 | n=120 | n=150 | n=118 | n=477 | n=144 | n=186 | n=147 |
| Mean (SD) | −5.0 (8.6) | −5.0 (8.8) | −1.9 (6.6) | −3.7 (7.1) | −9.7 (10.7) | −4.9 (8.5) | −1.4 (5.9) | −3.8 (6.9) | −9.7 (10.2) |
| Median (IQR) | −3.7 (−8.5 to −0.2) | −3.7 (−8.5 to −0.2) | −2.1 (−5.2 to 1.4) | −3.2 (−7.3 to 0.0) | −7.5 (−14.1 to −3.7) | −3.7 (−8.5 to −0.2) | −1.8 (−4.3 to 1.7) | −3.3 (−7.6 to −0.4) | −7.5 (−14.1 to −3.7) |
| eGFR slope, total (ml/min per 1.73 m2 per year) | n=510 | n=392 | n=121 | n=151 | n=120 | n=484 | n=147 | n=187 | n=150 |
| Mean (SD) | −5.3 (7.3) | −5.3 (7.6) | −2.9 (4.3) | −4.2 (6.2) | −8.9 (10.1) | −5.3 (7.3) | −2.2 (4.2) | −4.6 (5.6) | −9.1 (10.2) |
| Median (IQR) | −3.7 (−7.2 to −1.4) | −3.8 (−7.4 to −1.3) | −2.2 (−4.7 to −0.6) | −3.2 (−6.2 to −1.3) | −6.0 (−12.0 to −3.3) | −3.8 (−7.2 to −1.4) | −1.9 (−4.2 to −0.1) | −3.7 (−6.9 to −1.6) | −6.2 (−11.4 to −3.2) |
CI, confidence interval; HR, hazard ratio; NA, not available; IQR, interquartile range.
a
0.44 g/g=50 mg/mmol (approximately 0.5 g/d); 0.88 g/g=100 mg/mmol (approximately 1 g/d); 1.76 g/g=200 mg/mmol (approximately 2 g/d).