Table 2.
A summary of the voxel-based morphometry results
| Cluster | Anatomical Label | MNI (X/Y/Z) Coordinate | Total Number of Voxels | t-Value | ||
|---|---|---|---|---|---|---|
| WM volumes (FDR P < 0.01, ≥500 voxels) | ||||||
| 1 | Right supramarginal | 39 | −39 | 39 | 2226 | 12.24 |
| Right posterior central | 44 | −24 | 36 | 8.20 | ||
| Unclassified | 27 | −54 | 44 | 7.24 | ||
| 2 | Right middle frontal | 28 | 1 | 47 | 1311 | 9.82 |
| Right middle frontal | 25 | 15 | 47 | 8.13 | ||
| 3 | Right lateral occipital | 33 | −73 | −5 | 726 | 7.67 |
| 4 | Left superior temporal | −49 | −8 | −5 | 819 | 7.05 |
| Left planum temporale | −56 | −20 | 8 | 7.00 | ||
| Left superior temporal | −49 | −36 | 11 | 6.15 | ||
| GM volumes (FDR P < 0.01, ≥500 voxels) | ||||||
| 1 | Right thalamus | 16 | −28 | 16 | 839 | 9.72 |
| 2 | Left cerebellum | −34 | −60 | −22 | 1619 | 8.17 |
| Left lingual gyrus | −4 | −73 | −6 | 7.45 | ||
| Left lingual gyrus | −19 | −66 | −15 | 7.02 | ||
| 3 | Left middle cingulum | −2 | −22 | 40 | 624 | 6.70 |
| Left middle cingulum | −2 | −9 | 48 | 5.80 | ||
Anatomical description of local maxima of clusters of significant change in WM and GM volume at late-HD relative to pre-HD. Coordinates are given in anatomical MNI space, and the center of mass of each ROI is shown in bold. FDR, false discovery rate; WM, white matter; GM, gray matter; HD, hemodialysis; ROI, region of interest.