Comparison 1. Patch dose.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Smoking cessation	9		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1.1 21 mg versus 14 mg (24‐hour)	1	537	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [1.06, 2.08]
1.1.2 25 mg versus 15 mg (16‐hour)	3	3446	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [1.00, 1.41]
1.1.3 42/44 mg versus 21/22 mg (24‐hour)	5	1655	Risk Ratio (M‐H, Fixed, 95% CI)	1.09 [0.93, 1.29]
1.2 Fast or irregular heartbeat	2	3269	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.64, 1.33]
1.3 Myocardial infarction	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
1.4 Overall serious adverse events	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.4.1 42/44 mg versus 21/22 mg (24‐hour)	2	1023	Risk Ratio (M‐H, Fixed, 95% CI)	5.01 [0.87, 28.82]
1.4.2 21 mg versus 14 mg (24‐hour)	1	0	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
1.5 Treatment withdrawals	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.5.1 42/44 mg versus 21/22 mg (24‐hour)	2	554	Risk Ratio (M‐H, Fixed, 95% CI)	4.99 [1.60, 15.50]
1.5.2 21 mg versus 14 mg (24‐hour)	1	537	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.36, 1.64]