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. 2023 Jun 19;2023(6):CD013308. doi: 10.1002/14651858.CD013308.pub2

NCT03538938.

Study name Improving Quitline Support Study: optimizing remotely delivered smoking cessation services for low‐income smokers
Methods Four factor (2 x 2 x 2 x 2) factorial randomised controlled trial
Country: USA
Recruitment: at the follow‐up call 4 to 18 months after participating in the standard Wisconsin Tobacco Quit Line (WTQL) programme
Participants 1600 smokers still smoking 4 to 18 months after standard WTQL treatment; 18+ years old; uninsured, covered by a Medicaid programme, or has no more than high school education
Interventions 2 x 2 x 2 x 2 factorial design (16 possible treatment combinations):
1. Quit‐line counselling intensity
  • 1‐call quit‐line counselling

  • 4‐call quit‐line counselling


2. NRT intensity
  • Nicotine patch (< 10 cigarettes per day = 14 mg; ≥ 10 cigarettes per day = 21 mg) for 2 weeks

  • Nicotine patch and lozenge (< 10 cigarettes per day = 2 mg; ≥ 10 cigarettes per day = 4 mg) for 2 weeks.


3. SmokefreeTXT interactive text messages (up to 5 messages per day for up to 2 weeks prior to the target quit day and 6 weeks following the target quit day)
  • Enrolled in programme

  • Proactive information about enrolling


4. Financial incentives for treatment engagement
  • Financial incentives

  • No financial incentives

Outcomes 7‐day PPA at 6 months
Validation: saliva sample for cotinine testing with a value of < 4 ng/mL
Self‐reported abstinence at 12 weeks, continuous abstinence between 1 and 6 months
Adverse events: not listed as an outcome
Starting date 7 June 2018
Contact information Danielle E McCarthy, University of Wisconsin Center for Tobacco Research and Intervention, School of Medicine and Public Health
Notes Sponsor: Massachusetts General Hospital
Estimated study completion date: 1 January 2023