Fig. 5.

Photothermal effect of SW8@NPs under 808-/1,064-nm laser irradiation in vivo and its PTT of deep tumors. (A) One hundred microliters of SW8@NPs solution in a tube was covered with a piece of 15-mm-thick pork tissue, and temperature changes of SW8@NPs were recorded under laser (808/1,064 nm) irradiation. (B) Fluorescence images of 143B tumor-bearing mice (808-nm excitation, 1,000-nm-long pass, 0.27 W cm⁻², 200 ms). (C) Photothermal images of 143B tumor-bearing mice irradiated by laser (808 nm = 0.33 W cm⁻², 1,064 nm = 0.5 W cm⁻²). (D) Temperature profiles of tumor sites as functions of irradiation time (n = 3, *P < 0.05 vs. PBS + 1,064-nm laser). (E) X-ray images (60 kV, 20 ms) of mice at days 0, 6, and 12 after treatment. (F) Growth curves of in vivo tumor volumes. (G) High-definition photographs of mice and photographs of tumors removed on treatment day 12. The dashed circle indicated invisible tumors. (H) Weights of removed tumors (n = 3, *P < 0.05).