Table 2.
Major, minor, and genetic congenital malformations among pregnant women exposed to an mRNA COVID-19 vaccine in the first trimester compared to pregnant women exposed in the second and third trimesters of pregnancy.
| 1st trimester exposure |
2nd/3rd trimester exposure |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | 95%CI | n= |
1326 |
95%CI | RR | 95%CI | adj. RRb | 95%CI | |||||
| n | % | |||||||||||||
| Congenital malformationa | 1 | 0.81% | 0.02 | 4.41 | 11 | 0.83% | 0.41 | 1.48 | 0.89 | 0.12 | 6.80 | 1.01 | 0.13 | 7.73 |
| MAJOR | 1 | 0.81% | 0.02 | 4.41 | 6 | 0.45% | 0.17 | 0.98 | - | |||||
| Minor | 0 | - | 5 | 0.38% | 0.12 | 0.88 | - | |||||||
| Genetic malformation | 0 | - | 2 | 015% | 0.02 | 0.54 | - | |||||||
RR: risk ratio.
adj. RR: adjusted risk ratio.
a
Congenital malformation classification (major + minor) according to the EUROCAT classification.
b
adjusted analysis on unbalanced potential confounders: maternal age >40 years, drug use, nulliparity, medical history (pulmonary, diabetes and renal disease), and obstetrical history (previous pregnancy fetal malformation).