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. Author manuscript; available in PMC: 2023 Jun 19.
Published in final edited form as: J Proteomics. 2022 Jun 2;264:104636. doi: 10.1016/j.jprot.2022.104636

Fig. 3.

Fig. 3.

IL-4 induced the neutrophil signalome towards cytokine release and intracellular signaling response. A) Heat map shows the top 25 proteins upregulated or downregulated with IL-4 treatment. IL-4, IL-2 and IL-31 were the top three upregulated based on fold change. B) Volcano plot shows the top ranked differentially expressed proteins in neutrophils after IL-4 treatment. C) Enrichment analysis shows top 5 most enriched transcription factors based on p value. STAT3 was the most enriched transcription factor stimulated by IL-4. D) By enrichment analysis, cellular response to cytokine stimulus was the most enriched GO biological process in the IL-4 induced neutrophil signalome.