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. Author manuscript; available in PMC: 2023 Jun 19.
Published in final edited form as: J Proteomics. 2022 Jun 2;264:104636. doi: 10.1016/j.jprot.2022.104636

Fig. 4.

Fig. 4.

MMP-12 induced the neutrophil signalome towards apoptosis with a strong intracellular signaling response. A) Heat map shows the top 25 proteins upregulated or downregulated with MMP-12 treatment. IL-4, MIP-2 and SYK were the top three upregulated proteins based on fold change. B) Volcano plot shows top differentially expressed proteins in neutrophils after MMP-12 treatment. C) Enrichment analysis shows top 5 most enriched transcription factors based on p value. SP1 was the most enriched transcription factor stimulated by MMP-12. D) By enrichment analysis, protein phosphorylation was the most enriched GO biological process stimulated by MMP-12.