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. Author manuscript; available in PMC: 2023 Jun 19.
Published in final edited form as: J Proteomics. 2022 Jun 2;264:104636. doi: 10.1016/j.jprot.2022.104636

Fig. 7.

Fig. 7.

MMP-12 downregulated WNT signaling by proteolytically processing catenins and cadherins to reduce cell adhesion. A) MMP-12 cleaved β-catenin within 1 h of incubation. The catalytic domain of MMP-12 was incubated at a 5 (β-catenin): 1(MMP-12) ratio. B) MMP-12 cleaved cadherin-3 within 15 min of incubation. The catalytic domain of MMP-12 was incubated at a 5 (cadherin-3):1 (MMP-12) ratio. C) MMP-12 cleaved catenin-α2 within 15 min of incubation. The catalytic domain of MMP-12 was incubated at a 5 (catenin-α2):1 (MMP-12) ratio.