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. 2023 Jun 19;12(1):32. doi: 10.1038/s41389-023-00477-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Venn diagram showing the overlap between total peaks detected for N-MYC and WDR5 in IMR-32 cells. Overlap was called if individual peaks fall within 1 bp of each other. B Average normalized ChIP-seq fragment coverage for N-MYC at all sites centered at the TSS (red) compared to N-MYC at N-MYC–WDR5 cobound sites (blue) in IMR-32 cells. C Average normalized ChIP-seq fragment coverage for N-MYC at all sites centered at the TSS (red) compared to N-MYC at N-MYC–WDR5 cobound sites (blue) in CHP-134 cells. D Gene ontology enrichment analysis of genes that show N-MYC–WDR5 colocalization within 1 kb of their TSS in IMR-32 cells. The significance of enrichment is located on the x-axis and the numbers next to the red bars are the number of genes in each category. E Venn diagram showing the overlap between N-MYC–WDR5 cobound genes in each cell line. Only genes showing N-MYC–WDR5 bound within 1 kb of the gene were included. F Gene ontology enrichment analysis of 260 common genes from (E). Significance of enrichment is located on the x-axis and the numbers next to the red bars are the number of genes in each category. G Venn diagram showing the overlap of common N-MYC–WDR5 cobound sites with the conserved WDR5 binding sites across human cell lines [15] or c-MYC binding sites that are WBM-sensitive [9]. H Gene ontology enrichment analysis of 928 N-MYC-WDR5 cobound genes from (E) that are specific to CHP-134 cells. Significance of enrichment is located on the x-axis and the numbers next to the red bars are the number of genes in each category. RNP ribonucleoprotein.