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. 2023 Jun 19;8:252. doi: 10.1038/s41392-023-01495-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The neutralization against a variety of Omicron subvariants by convalescent sera from individuals recovered from BA.5 wave infection. a The schematic representation of the spike protein of SARS-CoV-2 Omicron BA.2 subvariants (up), and schematic depiction of the relationships between several circulating Omicron subvariants with the key amino acid substitutions (bottom). b The convalescent sera from 108 participants who infected with Omicron BA.5 subvariant from Dec 2022 to Jan 2023, in Chengdu, China were collected. Neutralizing antibody titers against prototype, Delta, BA.1, BA.2, BA.2.75, BA.3, BA.4/5, BF.7, BQ.1, BQ.1.1, XBB and XBB.1.5 pseudoviruses in convalescent sera were determined by pseudovirus neutralization assay. c Comparison of neutralizing antibody titers against live ancestral, Delta, BA.1, BA.2.75, BA.5 and XBB viruses. Data are presented as geometric mean values ± SD in (b, c). The GMT of 50% neutralization against pseudoviruses in (b) were only compared with BA.4/5 subvariant, and P values in (b) were determined by unpaired Student’s t tests, in (c) were performed by Two-way ANOVA followed by Sidak’s multiple comparisons test. ns not significant